Reaction Details Report a problem with these data
Target
Mothers against decapentaplegic homolog 3
Ligand
BDBM40312
Substrate
n/a
Meas. Tech.
SMAD Transcription Factor Inhibitors Dose Response Confirmation
IC50
8777±n/a nM
Citation
 PubChem, PC SMAD Transcription Factor Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Mothers against decapentaplegic homolog 3
Synonyms:
MADH3 | SMAD3 | SMAD3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48085.78
Organism:
Homo sapiens (Human)
Description:
gi_5174513
Residue:
425
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
  
Inhibitor
Name:
BDBM40312
Synonyms:
2-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-[[(4-oxidanylidene-6-propyl-1H-pyrimidin-2-yl)amino]-phenylazanyl-methylidene]propanamide | MLS000097134 | N-[anilino-[(4-keto-6-propyl-1H-pyrimidin-2-yl)amino]methylene]-2-phthalimido-propionamide | N-[anilino-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)amino]methylidene]-2-(1,3-dioxo-2-isoindolyl)propanamide | N-[anilino-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)amino]methylidene]-2-(1,3-dioxoisoindol-2-yl)propanamide | N-{anilino[(4-oxo-6-propyl-1,4-dihydro-2-pyrimidinyl)amino]methylene}-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide | SMR000076663 | cid_2955406
Type:
Small organic molecule
Emp. Form.:
C25H24N6O4
Mol. Mass.:
472.4959
SMILES:
CCCc1cc(=O)[nH]c(N=C(NC(=O)C(C)N2C(=O)c3ccccc3C2=O)Nc2ccccc2)n1 |w:9.8|
Structure:
Search PDB for entries with ligand similarity: