Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40422
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
Ki
>44300±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40422
Synonyms:
2-(3,4-dimethoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(3-morpholin-4-ylpropyl)-2H-pyrrol-5-one | 2-(3,4-dimethoxyphenyl)-3-(furan-2-ylcarbonyl)-1-(3-morpholin-4-ylpropyl)-4-oxidanyl-2H-pyrrol-5-one | 2-(3,4-dimethoxyphenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-[3-(4-morpholinyl)propyl]-2H-pyrrol-5-one | 5-(3,4-dimethoxyphenyl)-4-(2-furoyl)-3-hydroxy-1-(3-morpholinopropyl)-3-pyrrolin-2-one | UNM000003553701 | cid_2908584
Type:
Small organic molecule
Emp. Form.:
C24H28N2O7
Mol. Mass.:
456.4883
SMILES:
COc1ccc(cc1OC)C1C(C(=O)c2ccco2)C(=O)C(=O)N1CCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: