Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40440
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
IC50
10600±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40440
Synonyms:
2-(4-chlorophenyl)-4-hydroxy-1-(2-phenylethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one | 2-(4-chlorophenyl)-4-hydroxy-3-[oxo(thiophen-2-yl)methyl]-1-(2-phenylethyl)-2H-pyrrol-5-one | 2-(4-chlorophenyl)-4-oxidanyl-1-(2-phenylethyl)-3-thiophen-2-ylcarbonyl-2H-pyrrol-5-one | 5-(4-chlorophenyl)-3-hydroxy-1-phenethyl-4-(2-thenoyl)-3-pyrrolin-2-one | UNM000003599701 | cid_3880689
Type:
Small organic molecule
Emp. Form.:
C23H18ClNO3S
Mol. Mass.:
423.912
SMILES:
Clc1ccc(cc1)C1C(C(=O)c2cccs2)C(=O)C(=O)N1CCc1ccccc1
Structure:
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