Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM40480
Substrate
n/a
Meas. Tech.
Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation
EC50
23489.52±n/a nM
Citation
 PubChem, PC Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM40480
Synonyms:
2-[3-[3-(3-imidazol-1-ylpropyl)-4-keto-quinazolin-2-yl]propyl]isoindoline-1,3-quinone | 2-[3-[3-(3-imidazol-1-ylpropyl)-4-oxidanylidene-quinazolin-2-yl]propyl]isoindole-1,3-dione | 2-[3-[3-(3-imidazol-1-ylpropyl)-4-oxoquinazolin-2-yl]propyl]isoindole-1,3-dione | 2-[3-[3-[3-(1-imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione | 2-{3-[3-(3-Imidazol-1-yl-propyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-propyl}-isoindole-1,3-dione | MLS000073552 | SMR000010745 | cid_644964
Type:
Small organic molecule
Emp. Form.:
C25H23N5O3
Mol. Mass.:
441.4818
SMILES:
O=C1N(CCCc2nc3ccccc3c(=O)n2CCCn2ccnc2)C(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: