Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 1
Ligand
BDBM40694
Substrate
n/a
Meas. Tech.
High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters
IC50
12045±871 nM
Citation
 PubChem, PC High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters PubChem Bioassay (2008)[AID] 
Target
Name:
Nuclear receptor subfamily 4 group A member 1
Synonyms:
GFRP1 | HMR | NAK1 | NR4A1 | NR4A1_HUMAN | nuclear receptor subfamily 4, group A, member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64467.13
Organism:
Homo sapiens (Human)
Description:
gi_27894344
Residue:
598
Sequence:
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
  
Inhibitor
Name:
BDBM40694
Synonyms:
2-(2-furanyl)-4-quinolinecarboxylic acid [2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-2-oxoethyl] ester | 2-(2-furyl)cinchoninic acid [2-[4-(2-furoyl)piperazino]-2-keto-ethyl] ester | MLS000565090 | SMR000152303 | [2-[4-(furan-2-carbonyl)piperazin-1-yl]-2-oxoethyl] 2-(furan-2-yl)quinoline-4-carboxylate | [2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-2-oxidanylidene-ethyl] 2-(furan-2-yl)quinoline-4-carboxylate | cid_2434862
Type:
Small organic molecule
Emp. Form.:
C25H21N3O6
Mol. Mass.:
459.4507
SMILES:
O=C(COC(=O)c1cc(nc2ccccc12)-c1ccco1)N1CCN(CC1)C(=O)c1ccco1
Structure:
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