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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32161
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
>60000±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32161
Synonyms:
N-[4-amino-3-(5-methoxy-1,3-benzodioxol-4-yl)phenyl]-2,5-dichloro-benzenesulfonamide | N-[4-amino-3-(5-methoxy-1,3-benzodioxol-4-yl)phenyl]-2,5-dichlorobenzenesulfonamide | N-[4-azanyl-3-(5-methoxy-1,3-benzodioxol-4-yl)phenyl]-2,5-bis(chloranyl)benzenesulfonamide | TG2-77 | cid_16072255
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N2O5S
Mol. Mass.:
467.322
SMILES:
COc1ccc2OCOc2c1-c1cc(NS(=O)(=O)c2cc(Cl)ccc2Cl)ccc1N |(4.41,-4.62,;5.75,-3.85,;7.08,-4.62,;7.08,-6.16,;8.41,-6.93,;9.75,-6.16,;11.21,-6.63,;12.1,-5.39,;11.21,-4.15,;9.75,-4.62,;8.41,-3.85,;8.41,-2.31,;7.08,-1.54,;7.08,,;5.75,.77,;5.75,2.31,;4.21,2.31,;7.29,2.31,;5.75,3.85,;4.41,4.62,;4.41,6.16,;3.08,6.93,;5.75,6.93,;7.08,6.16,;7.08,4.62,;8.41,3.85,;8.41,.77,;9.75,,;9.75,-1.54,;11.29,-1.54,)|
Structure:
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