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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32178
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
>60000±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32178
Synonyms:
N-[4-amino-3-(2-ethoxy-1-naphthalenyl)phenyl]-3,4-dimethoxybenzenesulfonamide | N-[4-amino-3-(2-ethoxy-1-naphthyl)phenyl]-3,4-dimethoxy-benzenesulfonamide | N-[4-amino-3-(2-ethoxynaphthalen-1-yl)phenyl]-3,4-dimethoxybenzenesulfonamide | N-[4-azanyl-3-(2-ethoxynaphthalen-1-yl)phenyl]-3,4-dimethoxy-benzenesulfonamide | TG2-98-3 | cid_16072272
Type:
Small organic molecule
Emp. Form.:
C26H26N2O5S
Mol. Mass.:
478.56
SMILES:
CCOc1ccc2ccccc2c1-c1cc(NS(=O)(=O)c2ccc(OC)c(OC)c2)ccc1N |(3.08,7.08,;4.62,7.08,;5.39,5.75,;6.93,5.75,;6.93,7.29,;8.26,8.06,;9.6,7.29,;10.97,8.11,;12.37,7.32,;12.37,5.72,;10.97,4.93,;9.6,5.75,;8.26,4.98,;8.26,3.44,;9.6,2.67,;9.6,1.13,;10.93,.36,;10.93,-1.18,;12.47,-1.18,;9.39,-1.18,;10.93,-2.72,;12.26,-3.49,;12.26,-5.03,;10.93,-5.8,;10.93,-7.34,;12.26,-8.11,;9.6,-5.03,;8.26,-5.8,;8.26,-7.34,;9.6,-3.49,;8.26,.36,;6.93,1.13,;6.93,2.67,;5.39,2.67,)|
Structure:
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