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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32195
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
>50000±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32195
Synonyms:
4-chloranyl-N-[4-fluoranyl-3-(5-oxidanyl-1,3-benzodioxol-4-yl)phenyl]-3-nitro-benzenesulfonamide | 4-chloro-N-[4-fluoro-3-(5-hydroxy-1,3-benzodioxol-4-yl)phenyl]-3-nitro-benzenesulfonamide | 4-chloro-N-[4-fluoro-3-(5-hydroxy-1,3-benzodioxol-4-yl)phenyl]-3-nitrobenzenesulfonamide | TG1-218-2 | cid_16072279
Type:
Small organic molecule
Emp. Form.:
C19H12ClFN2O7S
Mol. Mass.:
466.824
SMILES:
Oc1ccc2OCOc2c1-c1cc(NS(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)ccc1F |(3.91,-4.62,;5.24,-5.39,;5.24,-6.93,;6.57,-7.7,;7.91,-6.93,;9.37,-7.4,;10.26,-6.16,;9.37,-4.92,;7.91,-5.39,;6.57,-4.62,;6.57,-3.08,;7.91,-2.31,;7.91,-.77,;9.24,,;9.24,1.54,;10.78,1.54,;7.7,1.54,;9.24,3.08,;7.91,3.85,;7.91,5.39,;9.24,6.16,;9.24,7.7,;10.58,5.39,;10.58,3.85,;11.91,6.16,;13.24,5.39,;11.91,7.7,;6.57,,;5.24,-.77,;5.24,-2.31,;3.91,-3.08,)|
Structure:
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