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Target
Cathepsin B
Ligand
BDBM41120
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM41120
Synonyms:
(5-bromanylpyridin-3-yl)-[4-(6-morpholin-4-ylpyridazin-3-yl)piperazin-1-yl]methanone | (5-bromo-3-pyridinyl)-[4-[6-(4-morpholinyl)-3-pyridazinyl]-1-piperazinyl]methanone | (5-bromo-3-pyridyl)-[4-(6-morpholinopyridazin-3-yl)piperazino]methanone | (5-bromopyridin-3-yl)-[4-(6-morpholin-4-ylpyridazin-3-yl)piperazin-1-yl]methanone | MLS000118464 | SMR000095405 | cid_5308489
Type:
Small organic molecule
Emp. Form.:
C18H21BrN6O2
Mol. Mass.:
433.302
SMILES:
Brc1cncc(c1)C(=O)N1CCN(CC1)c1ccc(nn1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: