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Target
Cathepsin B
Ligand
BDBM41122
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM41122
Synonyms:
MLS000120162 | N-(4-fluorobenzyl)-5-keto-1-phenethyl-pyrrolidine-2-carboxamide | N-[(4-fluorophenyl)methyl]-5-oxidanylidene-1-(2-phenylethyl)pyrrolidine-2-carboxamide | N-[(4-fluorophenyl)methyl]-5-oxo-1-(2-phenylethyl)-2-pyrrolidinecarboxamide | N-[(4-fluorophenyl)methyl]-5-oxo-1-(2-phenylethyl)pyrrolidine-2-carboxamide | SMR000097079 | cid_3422818
Type:
Small organic molecule
Emp. Form.:
C20H21FN2O2
Mol. Mass.:
340.3913
SMILES:
Fc1ccc(CNC(=O)C2CCC(=O)N2CCc2ccccc2)cc1
Structure:
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