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Target
Procathepsin L
Ligand
BDBM41177
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin L dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM41177
Synonyms:
4-[3,4-diketo-2-[4-(2-pyridyl)piperazino]cyclobuten-1-yl]piperazine-1-carboxylic acid ethyl ester | 4-[3,4-dioxo-2-[4-(2-pyridinyl)-1-piperazinyl]-1-cyclobutenyl]-1-piperazinecarboxylic acid ethyl ester | MLS000119358 | SMR000096279 | cid_5307747 | ethyl 4-[3,4-bis(oxidanylidene)-2-(4-pyridin-2-ylpiperazin-1-yl)cyclobuten-1-yl]piperazine-1-carboxylate | ethyl 4-[3,4-dioxo-2-(4-pyridin-2-ylpiperazin-1-yl)cyclobuten-1-yl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H25N5O4
Mol. Mass.:
399.4436
SMILES:
CCOC(=O)N1CCN(CC1)c1c(N2CCN(CC2)c2ccccn2)c(=O)c1=O
Structure:
Search PDB for entries with ligand similarity: