Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM41178
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response confirmation
IC50
12890.8±2524.09 nM
Citation
 PubChem, PC Cathepsin L dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM41178
Synonyms:
5-[(E)-2-(dimethylamino)ethenyl]-N-[3-[4-(4-methoxyphenyl)-1-piperazinyl]propyl]-3-methyl-4-isoxazolesulfonamide | 5-[(E)-2-(dimethylamino)ethenyl]-N-[3-[4-(4-methoxyphenyl)piperazin-1-yl]propyl]-3-methyl-1,2-oxazole-4-sulfonamide | 5-[(E)-2-(dimethylamino)vinyl]-N-[3-[4-(4-methoxyphenyl)piperazino]propyl]-3-methyl-isoxazole-4-sulfonamide | MLS000120315 | SMR000097231 | cid_5307860
Type:
Small organic molecule
Emp. Form.:
C22H33N5O4S
Mol. Mass.:
463.594
SMILES:
COc1ccc(cc1)N1CCN(CCCNS(=O)(=O)c2c(C)noc2\C=C\N(C)C)CC1
Structure:
Search PDB for entries with ligand similarity: