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Target
DNA-directed RNA polymerase subunit beta
Ligand
BDBM32058
Substrate
n/a
Meas. Tech.
RNA polymerase dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC RNA polymerase dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
DNA-directed RNA polymerase subunit beta
Synonyms:
RNA polymerase beta subunit (EC 2.7.7.6)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
150595.80
Organism:
Escherichia coli
Description:
A0A0E2LB94
Residue:
1342
Sequence:
MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE
  
Inhibitor
Name:
BDBM32058
Synonyms:
(3aR,6aS)-3-(3,4-dimethoxyphenyl)-5-(2,6-dimethylphenyl)-3a,6a-dihydropyrrol[3,4-d]isoxazole-4,6-quinone | (3aR,6aS)-3-(3,4-dimethoxyphenyl)-5-(2,6-dimethylphenyl)-3a,6a-dihydropyrrolo[3,4-d][1,2]oxazole-4,6-dione | (3aR,6aS)-3-(3,4-dimethoxyphenyl)-5-(2,6-dimethylphenyl)-3a,6a-dihydropyrrolo[3,4-d]isoxazole-4,6-dione | MLS000042301 | SMR000048612 | cid_667333
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5
Mol. Mass.:
380.3939
SMILES:
COc1ccc(cc1OC)-c1[nH]oc2c(O)n(-c3c(C)cccc3C)c(=O)c12 |(12.41,5.48,;13.44,4.33,;12.96,2.87,;11.46,2.55,;10.98,1.08,;12.01,-.06,;13.51,.26,;13.99,1.72,;15.5,2.04,;16.53,.89,;11.53,-1.53,;12.43,-2.77,;11.53,-4,;10.07,-3.54,;8.61,-4.01,;8.13,-5.48,;7.7,-2.77,;6.16,-2.77,;5.39,-1.43,;6.16,-.1,;3.85,-1.43,;3.08,-2.77,;3.85,-4.1,;5.39,-4.1,;6.16,-5.43,;8.61,-1.52,;8.13,-.05,;10.07,-2,)|
Structure:
Search PDB for entries with ligand similarity: