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Target
DNA-directed RNA polymerase subunit beta
Ligand
BDBM41251
Substrate
n/a
Meas. Tech.
RNA polymerase dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC RNA polymerase dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
DNA-directed RNA polymerase subunit beta
Synonyms:
RNA polymerase beta subunit (EC 2.7.7.6)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
150595.80
Organism:
Escherichia coli
Description:
A0A0E2LB94
Residue:
1342
Sequence:
MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE
  
Inhibitor
Name:
BDBM41251
Synonyms:
4-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]but-2-yn-1-ol | 4-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]thio]-2-butyn-1-ol | 4-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-yn-1-ol | 4-{[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]thio}but-2-yn-1-ol | MLS000043083 | SMR000019510 | cid_2928538
Type:
Small organic molecule
Emp. Form.:
C12H9BrN2O2S
Mol. Mass.:
325.181
SMILES:
OCC#CCSc1nnc(o1)-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: