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Target
Dual specificity protein phosphatase 6
Ligand
BDBM31753
Substrate
n/a
Meas. Tech.
MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors
IC50
5100±100 nM
Citation
 PubChem, PC MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM31753
Synonyms:
MLS-0067138.0001 | cid_16654632 | disodium;(7E)-8-keto-7-[(6-sulfonato-2-naphthyl)hydrazono]quinoline-5-sulfonate | disodium;(7E)-8-oxidanylidene-7-[(6-sulfonatonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonate | disodium;(7E)-8-oxo-7-[(6-sulfonato-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonate | disodium;(7E)-8-oxo-7-[(6-sulfonatonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonate
Type:
Small organic molecule
Emp. Form.:
C19H11N3O7S2
Mol. Mass.:
457.438
SMILES:
Oc1c(cc(c2cccnc12)S([O-])(=O)=O)N=Nc1ccc2cc(ccc2c1)S([O-])(=O)=O |w:16.18|
Structure:
Search PDB for entries with ligand similarity: