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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42317
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>50000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42317
Synonyms:
6-[[2-keto-2-(2-methylpiperidino)ethyl]thio]-7-piperonyl-[1,3]dioxolo[4,5-g]quinazolin-8-one | 7-(1,3-benzodioxol-5-ylmethyl)-6-[2-(2-methylpiperidin-1-yl)-2-oxidanylidene-ethyl]sulfanyl-[1,3]dioxolo[4,5-g]quinazolin-8-one | 7-(1,3-benzodioxol-5-ylmethyl)-6-[2-(2-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-[1,3]dioxolo[4,5-g]quinazolin-8-one | 7-(1,3-benzodioxol-5-ylmethyl)-6-[[2-(2-methyl-1-piperidinyl)-2-oxoethyl]thio]-[1,3]dioxolo[4,5-g]quinazolin-8-one | 7-(1,3-benzodioxol-5-ylmethyl)-6-{[2-(2-methylpiperidin-1-yl)-2-oxoethyl]thio}[1,3]dioxolo[4,5-g]quinazolin-8(7H)-one | MLS000095409 | SMR000030963 | cid_3236102
Type:
Small organic molecule
Emp. Form.:
C25H25N3O6S
Mol. Mass.:
495.548
SMILES:
CC1CCCCN1C(=O)CSc1nc2cc3OCOc3cc2c(=O)n1Cc1ccc2OCOc2c1
Structure:
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