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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42330
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>50000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42330
Synonyms:
2-[1-(4-fluorobenzoyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetic acid methyl ester | 2-[1-[(4-fluorophenyl)-oxomethyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetic acid methyl ester | MLS000047188 | SMR000033199 | cid_3238205 | methyl 2-[1-(4-fluorobenzoyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetate | methyl 2-[1-(4-fluorophenyl)carbonyl-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanoate | methyl [1-(4-fluorobenzoyl)-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl]acetate
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O3
Mol. Mass.:
342.3642
SMILES:
COC(=O)CN1CCN(C(=O)c2ccc(F)cc2)c2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: