Reaction Details Report a problem with these data
Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42358
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>10000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42358
Synonyms:
4-methyl-N-[2-methyl-1-(3-morpholinopropylcarbamoyl)propyl]cyclohexanecarboxamide | 4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxidanylidene-butan-2-yl]cyclohexane-1-carboxamide | 4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxobutan-2-yl]cyclohexane-1-carboxamide | 4-methyl-N-[3-methyl-1-[3-(4-morpholinyl)propylamino]-1-oxobutan-2-yl]-1-cyclohexanecarboxamide | MLS000095025 | SMR000030576 | cid_3243058
Type:
Small organic molecule
Emp. Form.:
C20H37N3O3
Mol. Mass.:
367.5261
SMILES:
CC(C)C(NC(=O)C1CCC(C)CC1)C(=O)NCCCN1CCOCC1 |(4.41,1.54,;4.41,,;3.08,-.77,;5.75,-.77,;5.75,-2.31,;4.41,-3.08,;3.08,-2.31,;4.41,-4.62,;3.08,-5.39,;3.08,-6.93,;4.41,-7.7,;4.41,-9.24,;5.75,-6.93,;5.75,-5.39,;7.08,,;8.41,-.77,;7.08,1.54,;8.41,2.31,;8.41,3.85,;9.75,4.62,;9.75,6.16,;8.41,6.93,;8.41,8.47,;9.75,9.24,;11.08,8.47,;11.08,6.93,)|
Structure:
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