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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42369
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>50000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42369
Synonyms:
1-(3-ethoxypropyl)-2-imino-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide | 1-(3-ethoxypropyl)-2-imino-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxodipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | 1-(3-ethoxypropyl)-2-imino-10-methyl-N-[2-(4-morpholinyl)ethyl]-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide | 1-(3-ethoxypropyl)-2-imino-5-keto-10-methyl-N-(2-morpholinoethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | 2-azanylidene-1-(3-ethoxypropyl)-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | MLS000085141 | SMR000019681 | cid_3244697
Type:
Small organic molecule
Emp. Form.:
C24H32N6O4
Mol. Mass.:
468.5487
SMILES:
CCOCCCn1c2nc3c(C)cccn3c(=O)c2cc(C(=O)NCCN2CCOCC2)c1=N
Structure:
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