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Target
Mitogen-activated protein kinase 10
Ligand
BDBM42813
Substrate
n/a
Meas. Tech.
Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3)
IC50
3259±n/a nM
Citation
 PubChem, PC Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3) PubChem Bioassay (2008)[AID] 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM42813
Synonyms:
4-[4-[(4-keto-2-thioxo-1H-quinazolin-3-yl)methyl]cyclohexanecarbonyl]piperazine-1-carboxylic acid ethyl ester | 4-[oxo-[4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexyl]methyl]-1-piperazinecarboxylic acid ethyl ester | MLS000049602 | SMR000076161 | cid_2952870 | ethyl 4-({4-[(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)methyl]cyclohexyl}carbonyl)-1-piperazinecarboxylate | ethyl 4-[4-[(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexyl]carbonylpiperazine-1-carboxylate | ethyl 4-[4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexanecarbonyl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H30N4O4S
Mol. Mass.:
458.574
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)C1CCC(Cn2c(=S)[nH]c3ccccc3c2=O)CC1 |(3.08,-.77,;4.41,-1.54,;5.75,-.77,;7.08,-1.54,;7.08,-3.08,;8.41,-.77,;9.75,-1.54,;11.08,-.77,;11.08,.77,;9.75,1.54,;8.41,.77,;12.42,1.54,;12.42,3.08,;13.75,.77,;15.08,1.54,;16.42,.77,;16.42,-.77,;17.75,-1.54,;19.08,-.77,;19.08,.77,;17.75,1.54,;20.42,1.54,;21.75,.77,;23.13,1.59,;24.52,.8,;24.52,-.8,;23.13,-1.59,;21.75,-.77,;20.42,-1.54,;20.42,-3.08,;15.08,-1.54,;13.75,-.77,)|
Structure:
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