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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33038
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
11380±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33038
Synonyms:
Acetic acid 4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxy-phenyl ester | MLS000073646 | SMR000010695 | [4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxy-phenyl] ethanoate | [4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenyl] acetate | acetic acid [4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxy-phenyl] ester | acetic acid [4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenyl] ester | cid_655850
Type:
Small organic molecule
Emp. Form.:
C20H18N2O3
Mol. Mass.:
334.3685
SMILES:
COc1cc(ccc1OC(C)=O)C1Nc2cccc3cccc(N1)c23
Structure:
Search PDB for entries with ligand similarity: