Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM33131
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
9150±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33131
Synonyms:
MLS000336087 | N-[(2-bromophenyl)methylideneamino]-7-chloranyl-quinolin-4-amine | N-[(2-bromophenyl)methylideneamino]-7-chloro-4-quinolinamine | N-[(2-bromophenyl)methylideneamino]-7-chloroquinolin-4-amine | SMR000253941 | [(2-bromobenzylidene)amino]-(7-chloro-4-quinolyl)amine | cid_3313154
Type:
Small organic molecule
Emp. Form.:
C16H11BrClN3
Mol. Mass.:
360.636
SMILES:
Clc1ccc2c(ccnc2c1)N=NCc1ccccc1Br |w:11.12|
Structure:
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