Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM32330
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
4560±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM32330
Synonyms:
(2Z)-2-(5-fluoranyl-2-oxidanylidene-indol-3-yl)-2-(4-methyl-3H-1,3-thiazol-2-ylidene)ethanenitrile | (2Z)-2-(5-fluoro-2-keto-indol-3-yl)-2-(4-methyl-4-thiazolin-2-ylidene)acetonitrile | (2Z)-2-(5-fluoro-2-oxo-3-indolyl)-2-(4-methyl-3H-thiazol-2-ylidene)acetonitrile | (2Z)-2-(5-fluoro-2-oxoindol-3-yl)-2-(4-methyl-3H-1,3-thiazol-2-ylidene)acetonitrile | MLS001011168 | SMR000353171 | cid_16196155
Type:
Small organic molecule
Emp. Form.:
C14H8FN3OS
Mol. Mass.:
285.296
SMILES:
Cc1csc(n1)C(C#N)=C1C(=O)Nc2ccc(F)cc12 |w:9.20|
Structure:
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