Target
Cell division control protein 42 homolog
Ligand
BDBM43218
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
3531±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43218
Synonyms:
(E)-3-(2,4-dichlorophenyl)-2-propenoic acid [2-(3-methoxyanilino)-2-oxoethyl] ester | (E)-3-(2,4-dichlorophenyl)acrylic acid [2-keto-2-(m-anisidino)ethyl] ester | MLS000390816 | SMR000259854 | [2-(3-methoxyanilino)-2-oxoethyl] (E)-3-(2,4-dichlorophenyl)prop-2-enoate | [2-[(3-methoxyphenyl)amino]-2-oxidanylidene-ethyl] (E)-3-(2,4-dichlorophenyl)prop-2-enoate | cid_2343044
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2NO4
Mol. Mass.:
380.222
SMILES:
COc1cccc(NC(=O)COC(=O)\C=C\c2ccc(Cl)cc2Cl)c1
Structure:
Search PDB for entries with ligand similarity: