Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM43227
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
11340±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43227
Synonyms:
1-[2-(4-chlorophenyl)ethylamino]-3-(2-naphthalenyloxy)-2-propanol | 1-[2-(4-chlorophenyl)ethylamino]-3-(2-naphthoxy)propan-2-ol | 1-[2-(4-chlorophenyl)ethylamino]-3-naphthalen-2-yloxy-propan-2-ol | 1-[2-(4-chlorophenyl)ethylamino]-3-naphthalen-2-yloxypropan-2-ol | MLS000772350 | SMR000344505 | cid_4388447
Type:
Small organic molecule
Emp. Form.:
C21H22ClNO2
Mol. Mass.:
355.858
SMILES:
OC(CNCCc1ccc(Cl)cc1)COc1ccc2ccccc2c1
Structure:
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