Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM43229
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
12880±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43229
Synonyms:
4-mesyl-3-nitro-benzoic acid [2-(cyclohexanecarbonylamino)-2-keto-ethyl] ester | 4-methylsulfonyl-3-nitrobenzoic acid [2-[[cyclohexyl(oxo)methyl]amino]-2-oxoethyl] ester | MLS000517530 | SMR000343499 | [2-(cyclohexanecarbonylamino)-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate | [2-(cyclohexylcarbonylamino)-2-oxidanylidene-ethyl] 4-methylsulfonyl-3-nitro-benzoate | cid_2475979
Type:
Small organic molecule
Emp. Form.:
C17H20N2O8S
Mol. Mass.:
412.414
SMILES:
CS(=O)(=O)c1ccc(cc1[N+]([O-])=O)C(=O)OCC(=O)NC(=O)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: