Reaction Details Report a problem with these data
Target
Ras-related protein Rab-2A
Ligand
BDBM43256
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
850.6±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM43256
Synonyms:
7-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-3-(2-methoxyethyl)-2-sulfanylidene-1H-quinazolin-4-one | 7-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-3-(2-methoxyethyl)-2-sulfanylidene-1H-quinazolin-4-one | 7-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-3-(2-methoxyethyl)-2-thioxo-1H-quinazolin-4-one | 7-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-3-(2-methoxyethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one | 7-[3,4-dihydro-1H-isoquinolin-2-yl(oxo)methyl]-3-(2-methoxyethyl)-2-sulfanylidene-1H-quinazolin-4-one | MLS000661014 | SMR000310652 | cid_4194153
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3S
Mol. Mass.:
395.475
SMILES:
COCCn1c(=S)[nH]c2cc(ccc2c1=O)C(=O)N1CCc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: