Reaction Details Report a problem with these data
Target
Ras-related protein Rab-2A
Ligand
BDBM43223
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
6260±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM43223
Synonyms:
2-(2,3,5,6-tetramethylbenzoyl)benzoic acid | 2-(2,3,5,6-tetramethylphenyl)carbonylbenzoic acid | 2-[oxo-(2,3,5,6-tetramethylphenyl)methyl]benzoic acid | MLS000714513 | SMR000274492 | cid_803711
Type:
Small organic molecule
Emp. Form.:
C18H18O3
Mol. Mass.:
282.3337
SMILES:
Cc1cc(C)c(C)c(C(=O)c2ccccc2C(O)=O)c1C
Structure:
Search PDB for entries with ligand similarity: