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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43260
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
14180±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43260
Synonyms:
4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-3-methoxybenzoic acid [2-[(2,2-difluoro-1,3-benzodioxol-5-yl)amino]-2-oxoethyl] ester | 4-[(3,5-dimethylisoxazol-4-yl)methoxy]-3-methoxy-benzoic acid [2-[(2,2-difluoro-1,3-benzodioxol-5-yl)amino]-2-keto-ethyl] ester | MLS000055954 | SMR000068351 | [2-[(2,2-difluoro-1,3-benzodioxol-5-yl)amino]-2-oxoethyl] 4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-3-methoxybenzoate | [2-[[2,2-bis(fluoranyl)-1,3-benzodioxol-5-yl]amino]-2-oxidanylidene-ethyl] 4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-3-methoxy-benzoate | cid_2549881
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O8
Mol. Mass.:
490.4103
SMILES:
COc1cc(ccc1OCc1c(C)noc1C)C(=O)OCC(=O)Nc1ccc2OC(F)(F)Oc2c1
Structure:
Search PDB for entries with ligand similarity: