Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43218
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
13330±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43218
Synonyms:
(E)-3-(2,4-dichlorophenyl)-2-propenoic acid [2-(3-methoxyanilino)-2-oxoethyl] ester | (E)-3-(2,4-dichlorophenyl)acrylic acid [2-keto-2-(m-anisidino)ethyl] ester | MLS000390816 | SMR000259854 | [2-(3-methoxyanilino)-2-oxoethyl] (E)-3-(2,4-dichlorophenyl)prop-2-enoate | [2-[(3-methoxyphenyl)amino]-2-oxidanylidene-ethyl] (E)-3-(2,4-dichlorophenyl)prop-2-enoate | cid_2343044
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2NO4
Mol. Mass.:
380.222
SMILES:
COc1cccc(NC(=O)COC(=O)\C=C\c2ccc(Cl)cc2Cl)c1
Structure:
Search PDB for entries with ligand similarity: