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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43222
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
28000±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43222
Synonyms:
4-(2-bromanyl-4-methyl-phenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methyl-phenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methylphenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | MLS000765201 | SMR000288606 | cid_931740
Type:
Small organic molecule
Emp. Form.:
C13H10BrN5S
Mol. Mass.:
348.221
SMILES:
Cc1ccc(c(Br)c1)-n1c(n[nH]c1=S)-c1cnccn1 |(5.79,-4.65,;5.79,-3.11,;7.12,-2.34,;7.12,-.8,;5.79,-.03,;4.46,-.8,;3.12,-.03,;4.46,-2.34,;5.79,1.51,;7.04,2.41,;6.56,3.88,;5.02,3.88,;4.54,2.41,;3.08,1.94,;8.5,1.94,;8.82,.43,;10.29,-.04,;11.43,.99,;11.11,2.49,;9.65,2.97,)|
Structure:
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