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Target
Cyclin-dependent kinase 7
Ligand
BDBM32361
Substrate
n/a
Meas. Tech.
CDK7 counterscreen of confirmed PKD inhibitors-57K library addition
IC50
>100000±n/a nM
Citation
 PubChem, PC CDK7 counterscreen of confirmed PKD inhibitors-57K library addition PubChem Bioassay (2008)[AID] 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM32361
Synonyms:
2-[4-[(4-keto-6-propyl-1H-pyrimidin-2-yl)thio]butyl]isoindoline-1,3-quinone | 2-[4-[(4-oxidanylidene-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butyl]isoindole-1,3-dione | 2-[4-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butyl]isoindole-1,3-dione | 2-[4-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)thio]butyl]isoindole-1,3-dione | MLS000761528 | SMR000371639 | cid_2097425
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3S
Mol. Mass.:
371.453
SMILES:
CCCc1cc(=O)[nH]c(SCCCCN2C(=O)c3ccccc3C2=O)n1
Structure:
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