Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM32342
Substrate
n/a
Meas. Tech.
PLK1 counterscreening assay for identified PKD inhibitors
IC50
410±n/a nM
Citation
 PubChem, PC PLK1 counterscreening assay for identified PKD inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM32342
Synonyms:
(2-amino-6-nitro-1,3-benzothiazol-7-yl)amine | 2,7-diamino-6-nitro-1,3-benzothiazole | 6-nitro-1,3-benzothiazole-2,7-diamine | MLS000545094 | SMR000163601 | cid_5086667
Type:
Small organic molecule
Emp. Form.:
C7H6N4O2S
Mol. Mass.:
210.213
SMILES:
Nc1nc2ccc(c(N)c2s1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: