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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43370
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
13250±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43370
Synonyms:
2-(1-ethyl-2,4-diketo-quinazolin-3-yl)-N-(3,4,5-trimethoxyphenyl)acetamide | 2-(1-ethyl-2,4-dioxo-3-quinazolinyl)-N-(3,4,5-trimethoxyphenyl)acetamide | 2-(1-ethyl-2,4-dioxoquinazolin-3-yl)-N-(3,4,5-trimethoxyphenyl)acetamide | 2-[1-ethyl-2,4-bis(oxidanylidene)quinazolin-3-yl]-N-(3,4,5-trimethoxyphenyl)ethanamide | MLS000521250 | SMR000131658 | cid_5146720
Type:
Small organic molecule
Emp. Form.:
C21H23N3O6
Mol. Mass.:
413.4238
SMILES:
CCn1c2ccccc2c(=O)n(CC(=O)Nc2cc(OC)c(OC)c(OC)c2)c1=O
Structure:
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