Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43405
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
12580±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43405
Synonyms:
5-(3-chlorophenyl)-2-[(cyclopentylamino)methylene]cyclohexane-1,3-dione | 5-(3-chlorophenyl)-2-[(cyclopentylamino)methylene]cyclohexane-1,3-quinone | 5-(3-chlorophenyl)-2-[(cyclopentylamino)methylidene]cyclohexane-1,3-dione | MLS000586114 | SMR000204477 | cid_4599064
Type:
Small organic molecule
Emp. Form.:
C18H20ClNO2
Mol. Mass.:
317.81
SMILES:
Clc1cccc(c1)C1CC(=O)C(=CNC2CCCC2)C(=O)C1 |(10.37,5.32,;8.83,5.32,;8.06,6.65,;6.52,6.65,;5.75,5.32,;6.52,3.98,;8.06,3.98,;5.75,2.65,;7.08,1.88,;7.08,.34,;8.41,-.43,;5.75,-.43,;5.75,-1.97,;4.41,-2.74,;4.41,-4.28,;3.17,-5.19,;3.64,-6.65,;5.18,-6.65,;5.66,-5.19,;4.41,.34,;3.08,-.43,;4.41,1.88,)|
Structure:
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