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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43424
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
1890±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43424
Synonyms:
2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]-N-(cyclohexylmethyl)ethanamide | MLS000390353 | N-(cyclohexylmethyl)-2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetamide | N-(cyclohexylmethyl)-2-(4,5-dichloro-6-oxo-1-pyridazinyl)acetamide | N-(cyclohexylmethyl)-2-(4,5-dichloro-6-oxopyridazin-1-yl)acetamide | SMR000255320 | cid_2585197
Type:
Small organic molecule
Emp. Form.:
C13H17Cl2N3O2
Mol. Mass.:
318.199
SMILES:
Clc1cnn(CC(=O)NCC2CCCCC2)c(=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: