Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43431
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
6730±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43431
Synonyms:
(5E)-5-[(5-morpholin-4-ylfuran-2-yl)methylidene]-3-phenyl-imidazolidine-2,4-dione | (5E)-5-[(5-morpholin-4-ylfuran-2-yl)methylidene]-3-phenylimidazolidine-2,4-dione | (5E)-5-[(5-morpholino-2-furyl)methylene]-3-phenyl-hydantoin | (5E)-5-[[5-(4-morpholinyl)-2-furanyl]methylidene]-3-phenylimidazolidine-2,4-dione | 5-{[5-(4-morpholinyl)-2-furyl]methylene}-3-phenyl-2,4-imidazolidinedione | MLS000676857 | SMR000271862 | cid_2176608
Type:
Small organic molecule
Emp. Form.:
C18H17N3O4
Mol. Mass.:
339.3453
SMILES:
O=C1NC(=Cc2ccc(o2)N2CCOCC2)C(=O)N1c1ccccc1 |w:4.4|
Structure:
Search PDB for entries with ligand similarity: