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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43434
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
12310±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43434
Synonyms:
3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone | 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-4-thiazolyl]methanone | 3,4-dihydro-1H-isoquinolin-2-yl-[2-(p-anisidino)thiazol-4-yl]methanone | 3,4-dihydro-1H-isoquinolin-2-yl-[2-[(4-methoxyphenyl)amino]-1,3-thiazol-4-yl]methanone | MLS000718305 | SMR000290573 | cid_1096735
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2S
Mol. Mass.:
365.449
SMILES:
COc1ccc(Nc2nc(cs2)C(=O)N2CCc3ccccc3C2)cc1
Structure:
Search PDB for entries with ligand similarity: