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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43435
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
3273410±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43435
Synonyms:
1'-{[5-(hydroxymethyl)-2-furyl]methyl}-N-(2-phenylethyl)-1,4'-bipiperidine-4-carboxamide | 1-[1-[(5-methylol-2-furyl)methyl]-4-piperidyl]-N-phenethyl-isonipecotamide | 1-[1-[[5-(hydroxymethyl)-2-furanyl]methyl]-4-piperidinyl]-N-(2-phenylethyl)-4-piperidinecarboxamide | 1-[1-[[5-(hydroxymethyl)furan-2-yl]methyl]piperidin-4-yl]-N-(2-phenylethyl)piperidine-4-carboxamide | MLS000732998 | SMR000317864 | cid_16187723
Type:
Small organic molecule
Emp. Form.:
C25H35N3O3
Mol. Mass.:
425.5637
SMILES:
OCc1ccc(CN2CCC(CC2)N2CCC(CC2)C(=O)NCCc2ccccc2)o1
Structure:
Search PDB for entries with ligand similarity: