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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43449
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
11060±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43449
Synonyms:
(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-(2-furanyl)methanone | (6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-(2-furyl)methanone | (6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-(furan-2-yl)methanone | MLS000766095 | SMR000279801 | cid_751492
Type:
Small organic molecule
Emp. Form.:
C16H17NO4
Mol. Mass.:
287.3105
SMILES:
COc1cc2CCN(Cc2cc1OC)C(=O)c1ccco1
Structure:
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