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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43452
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
2940±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43452
Synonyms:
6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-4-(4-methylpiperazin-1-yl)carbonyl-3,4-dihydroisoquinolin-1-one | 6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)-3,4-dihydroisocarbostyril | 6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)-3,4-dihydroisoquinolin-1-one | 6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-4-[(4-methyl-1-piperazinyl)-oxomethyl]-3,4-dihydroisoquinolin-1-one | 6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-4-[(4-methylpiperazin-1-yl)carbonyl]-3,4-dihydroisoquinolin-1(2H)-one | MLS000729860 | SMR000308137 | cid_4220985
Type:
Small organic molecule
Emp. Form.:
C25H31N3O5
Mol. Mass.:
453.5307
SMILES:
COc1ccc(cc1)C1C(C(=O)N2CCN(C)CC2)c2cc(OC)c(OC)cc2C(=O)N1C
Structure:
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