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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43468
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
8140±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43468
Synonyms:
2-[4-[1-(2-chlorobenzyl)-2,4-diketo-quinazolin-3-yl]phenyl]-N-(tetrahydrofurfuryl)acetamide | 2-[4-[1-[(2-chlorophenyl)methyl]-2,4-bis(oxidanylidene)quinazolin-3-yl]phenyl]-N-(oxolan-2-ylmethyl)ethanamide | 2-[4-[1-[(2-chlorophenyl)methyl]-2,4-dioxo-3-quinazolinyl]phenyl]-N-(2-oxolanylmethyl)acetamide | 2-[4-[1-[(2-chlorophenyl)methyl]-2,4-dioxoquinazolin-3-yl]phenyl]-N-(oxolan-2-ylmethyl)acetamide | 2-{4-[1-(2-chlorobenzyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]phenyl}-N-(tetrahydrofuran-2-ylmethyl)acetamide | MLS000730472 | SMR000308748 | cid_16195160
Type:
Small organic molecule
Emp. Form.:
C28H26ClN3O4
Mol. Mass.:
503.977
SMILES:
Clc1ccccc1Cn1c2ccccc2c(=O)n(-c2ccc(CC(=O)NCC3CCCO3)cc2)c1=O
Structure:
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