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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43493
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
3550±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43493
Synonyms:
MLS000859879 | N-[4-(1,2,3-thiadiazol-4-yl)phenyl]cyclopropanecarboxamide | N-[4-(4-thiadiazolyl)phenyl]cyclopropanecarboxamide | N-[4-(thiadiazol-4-yl)phenyl]cyclopropanecarboxamide | N1-[4-(1,2,3-thiadiazol-4-yl)phenyl]cyclopropane-1-carboxamide | SMR000460858 | cid_2739181
Type:
Small organic molecule
Emp. Form.:
C12H11N3OS
Mol. Mass.:
245.3
SMILES:
O=C(Nc1ccc(cc1)-c1csnn1)C1CC1
Structure:
Search PDB for entries with ligand similarity: