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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43494
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
43180±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43494
Synonyms:
2-[(2-pyridin-2-yl-2,3-dihydro-1,3,4-thiadiazol-5-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]acetamide | 2-[(2-pyridin-2-yl-2,3-dihydro-1,3,4-thiadiazol-5-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]ethanamide | 2-[[2-(2-pyridinyl)-2,3-dihydro-1,3,4-thiadiazol-5-yl]thio]-N-[4-(trifluoromethyl)phenyl]acetamide | 2-[[2-(2-pyridyl)-2,3-dihydro-1,3,4-thiadiazol-5-yl]thio]-N-[4-(trifluoromethyl)phenyl]acetamide | MLS000861739 | N1-[4-(trifluoromethyl)phenyl]-2-{[5-(2-pyridyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]thio}acetamide | SMR000460523 | cid_2746661
Type:
Small organic molecule
Emp. Form.:
C16H13F3N4OS2
Mol. Mass.:
398.426
SMILES:
FC(F)(F)c1ccc(NC(=O)CSC2=NNC(S2)c2ccccn2)cc1 |t:13|
Structure:
Search PDB for entries with ligand similarity: