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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43497
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
19250±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43497
Synonyms:
2-N-benzyl-2-N-[2-(dimethylamino)ethyl]-6-N-methyl-6-N-phenyl-9-propan-2-ylpurine-2,6-diamine | MLS000911541 | N2-[2-(dimethylamino)ethyl]-N6-methyl-N6-phenyl-N2-(phenylmethyl)-9-propan-2-yl-purine-2,6-diamine | N2-[2-(dimethylamino)ethyl]-N6-methyl-N6-phenyl-N2-(phenylmethyl)-9-propan-2-ylpurine-2,6-diamine | SMR000463557 | benzyl-[2-(dimethylamino)ethyl]-[9-isopropyl-6-(N-methylanilino)purin-2-yl]amine | cid_16746000
Type:
Small organic molecule
Emp. Form.:
C26H33N7
Mol. Mass.:
443.5871
SMILES:
CC(C)n1cnc2c(nc(nc12)N(CCN(C)C)Cc1ccccc1)N(C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: