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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM43532
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT1 inhibition
IC50
13330±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT1 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM43532
Synonyms:
11,11-dimethyl-3-(pyrrolidine-1-carbonyl)-10H-naphth[1,2-g]indolizine-1,2-quinone | 11,11-dimethyl-3-(pyrrolidine-1-carbonyl)-10H-naphtho[1,2-g]indolizine-1,2-dione | 11,11-dimethyl-3-[oxo(1-pyrrolidinyl)methyl]-10H-naphtho[1,2-g]indolizine-1,2-dione | 11,11-dimethyl-3-pyrrolidin-1-ylcarbonyl-10H-naphtho[1,2-g]indolizine-1,2-dione | 6,6-dimethyl-10-(pyrrolidin-1-ylcarbonyl)-5,6-dihydrobenzo[f]pyrrolo[2,1-a]isoquinoline-8,9-dione | MLS000728879 | SMR000307157 | cid_5026241
Type:
Small organic molecule
Emp. Form.:
C23H22N2O3
Mol. Mass.:
374.4324
SMILES:
CC1(C)Cc2c(ccc3ccccc23)C2=C(C(=O)N3CCCC3)C(=O)C(=O)N12 |c:16|
Structure:
Search PDB for entries with ligand similarity: