Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43567
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
>55700±n/a nM
Citation
More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM43567
Synonyms:
3-(1H-indol-3-yl)-1-keto-N-[3-(2-ketopyrrolidino)propyl]-2-methyl-3,4-dihydroisoquinoline-4-carboxamide | 3-(1H-indol-3-yl)-2-methyl-1-oxidanylidene-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]-3,4-dihydroisoquinoline-4-carboxamide | 3-(1H-indol-3-yl)-2-methyl-1-oxo-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-3,4-dihydroisoquinoline-4-carboxamide | 3-(1H-indol-3-yl)-2-methyl-1-oxo-N-[3-(2-oxopyrrolidin-1-yl)propyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide | 3-(1H-indol-3-yl)-2-methyl-1-oxo-N-[3-(2-oxopyrrolidin-1-yl)propyl]-3,4-dihydroisoquinoline-4-carboxamide | MLS000090886 | SMR000025489 | cid_3241758
Type:
Small organic molecule
Emp. Form.:
C26H28N4O3
Mol. Mass.:
444.5255
SMILES:
CN1C(C(C(=O)NCCCN2CCCC2=O)c2ccccc2C1=O)c1c[nH]c2ccccc12
Structure:
