Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43623
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
13700±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43623
Synonyms:
1-(2-fluorophenyl)-2-([1,2,4]triazolo[1,5-a]pyrimidin-6-ylacetyl)-2,3,4,9-tetrahydro-1H-beta-carboline | 1-[1-(2-fluorophenyl)-1,3,4,9-tetrahydro-beta-carbolin-2-yl]-2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethanone | 1-[1-(2-fluorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethanone | MLS000735924 | SMR000319548 | cid_16187604
Type:
Small organic molecule
Emp. Form.:
C24H19FN6O
Mol. Mass.:
426.4457
SMILES:
Fc1ccccc1C1N(CCc2c1[nH]c1ccccc21)C(=O)Cc1cnc2ncnn2c1
Structure:
Search PDB for entries with ligand similarity: