Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM43640
Substrate
n/a
Meas. Tech.
Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation
EC50
>55700±n/a nM
Citation
PubChem, PC Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation PubChem Bioassay (2008)[AID]
More Info.:
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
Inhibitor
Name:
BDBM43640
Synonyms:
1-(2-fluoro-4-methoxyphenyl)-2-(pyrazolo[1,5-a]pyrimidin-2-ylcarbonyl)-2,3,4,9-tetrahydro-1H-beta-carboline | MLS000734183 | SMR000318378 | [1-(2-fluoranyl-4-methoxy-phenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-pyrazolo[1,5-a]pyrimidin-2-yl-methanone | [1-(2-fluoro-4-methoxy-phenyl)-1,3,4,9-tetrahydro-beta-carbolin-2-yl]-pyrazolo[1,5-a]pyrimidin-2-yl-methanone | [1-(2-fluoro-4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-(2-pyrazolo[1,5-a]pyrimidinyl)methanone | [1-(2-fluoro-4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-pyrazolo[1,5-a]pyrimidin-2-ylmethanone | cid_16192118
Type:
Small organic molecule
Emp. Form.:
C25H20FN5O2
Mol. Mass.:
441.457
SMILES:
COc1ccc(C2N(CCc3c2[nH]c2ccccc32)C(=O)c2cc3ncccn3n2)c(F)c1