Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43798
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay
EC50
27400±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43798
Synonyms:
(1-benzylbenzimidazol-2-yl)methyl-[1-(2-piperidinoethyl)benzimidazol-2-yl]amine | MLS-0083130.0001 | N-[(1-benzylbenzimidazol-2-yl)methyl]-1-(2-piperidin-1-ylethyl)benzimidazol-2-amine | N-[[1-(phenylmethyl)-2-benzimidazolyl]methyl]-1-[2-(1-piperidinyl)ethyl]-2-benzimidazolamine | N-[[1-(phenylmethyl)benzimidazol-2-yl]methyl]-1-(2-piperidin-1-ylethyl)benzimidazol-2-amine | cid_1043331
Type:
Small organic molecule
Emp. Form.:
C29H32N6
Mol. Mass.:
464.6046
SMILES:
C(Cn1c(NCc2nc3ccccc3n2Cc2ccccc2)nc2ccccc12)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: